Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy

Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy

Abstract The induction of apoptosis is a direct way to eliminate tumor cells and improve cancer therapy. Apoptosis is tightly controlled by the balance of pro- and antiapoptotic Bcl-2 proteins. BH3 mimetics neutralize the antiapoptotic function of Bcl-2 proteins and are highly promising compounds in...

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Bibliographic Details
Main Authors: Vinzenz Särchen, Senthan Shanmugalingam, Sarah Kehr, Lisa Marie Reindl, Victoria Greze, Sara Wiedemann, Cathinka Boedicker, Maureen Jacob, Katrin Bankov, Nina Becker, Sibylle Wehner, Till M. Theilen, Steffen Gretser, Elise Gradhand, Carsten Kummerow, Evelyn Ullrich, Meike Vogler
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00812-6

Internet

https://doi.org/10.1038/s41420-021-00812-6

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