Proteolytic shedding of CD46 from human hepatocytes indicates liver stress

Proteolytic shedding of CD46 from human hepatocytes indicates liver stress

Background: Routine liver function tests capture information about the metabolic and inflammatory condition of the liver, but we lack sensitive biomarkers of early hepatocyte stress. In humans, soluble CD46 (sCD46) levels in blood were recently identified as an accurate biomarker of hepatic steatosi...

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Bibliographic Details
Main Authors: Paul Kupke, Jordi Yang Zhou, Gunther Glehr, Paloma Riquelme, Lena Scheibert, Akinbami Adenugba, Hans J. Schlitt, Edward K. Geissler, Jens M. Werner, James A. Hutchinson
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Soluble CD46
Steatotic liver disease
Hepatic stress
Liver inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024168727

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http://www.sciencedirect.com/science/article/pii/S2405844024168727

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