Unique effect of clozapine on adenosine A2A-dopamine D2 receptor heteromerization

Unique effect of clozapine on adenosine A2A-dopamine D2 receptor heteromerization

The striatal dopamine D2 receptor (D2R) is generally accepted to be involved in positive symptoms of schizophrenia and is a main target for clinically used antipsychotics. D2R are highly expressed in the striatum, where they form heteromers with the adenosine A2A receptor (A2AR). Changes in the dens...

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Bibliographic Details
Main Authors: Marta Valle-León, Nil Casajuana-Martin, Claudia Llinas del Torrent, Josep Argerich, Laura Gómez-Acero, Kristoffer Sahlholm, Sergi Ferré, Leonardo Pardo, Francisco Ciruela
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Clozapine
Haloperidol
Aripiprazole
Dopamine D2 receptor
Adenosine A2A receptor
Receptor heteromerization
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223001154

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223001154

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