Unique effect of clozapine on adenosine A2A-dopamine D2 receptor heteromerization

Unique effect of clozapine on adenosine A2A-dopamine D2 receptor heteromerization

The striatal dopamine D2 receptor (D2R) is generally accepted to be involved in positive symptoms of schizophrenia and is a main target for clinically used antipsychotics. D2R are highly expressed in the striatum, where they form heteromers with the adenosine A2A receptor (A2AR). Changes in the dens...

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Bibliographic Details
Main Authors:	Marta Valle-León, Nil Casajuana-Martin, Claudia Llinas del Torrent, Josep Argerich, Laura Gómez-Acero, Kristoffer Sahlholm, Sergi Ferré, Leonardo Pardo, Francisco Ciruela
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Clozapine Haloperidol Aripiprazole Dopamine D2 receptor Adenosine A2A receptor Receptor heteromerization
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332223001154

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