Topiramate versus naltrexone for alcohol use disorder: study protocol for a genotype-stratified, double-blind randomised controlled trial (TOP study)

Topiramate versus naltrexone for alcohol use disorder: study protocol for a genotype-stratified, double-blind randomised controlled trial (TOP study)

Abstract Background Current treatments for alcohol use disorders have limited efficacy and there is a high degree of variability in treatment response. In a randomised, placebo-controlled clinical trial, there was a large effect size for topiramate in people homozygous for the GRIK1 rs2832407*C alle...

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Bibliographic Details
Main Authors: Kirsten C. Morley, Henry R. Kranzler, Natasha Luquin, Andrew Baillie, Marian Shanahan, Ronald Trent, Maree Teesson, Paul S. Haber
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Trials
Subjects:
Topiramate
Alcohol use disorder
Pharmacogenetics
Naltrexone
Alcohol dependence
GRIK1
Online Access:http://link.springer.com/article/10.1186/s13063-018-2824-z

Internet

http://link.springer.com/article/10.1186/s13063-018-2824-z

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