Antinociceptive and Abuse Potential Effects of Cannabinoid/Opioid Combinations in a Chronic Pain Model in Rats

Chronic pain is a persistent and debilitating health problem. Although the use of analgesics such as opioids is useful in mitigating pain, their prolonged use is associated with unwanted effects including abuse liability. This study assesses the antinociceptive effect of combining subtherapeutic dos...

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Bibliographic Details
Main Authors: Mohammad Alsalem, Ahmad Altarifi, Mansour Haddad, Sara A. Aldossary, Heba Kalbouneh, Nour Aldaoud, Tareq Saleh, Khalid El-Salem
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Brain Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3425/9/11/328