Inducible Costimulator Expressing T Cells Promote Parasitic Growth During Blood Stage Plasmodium berghei ANKA Infection

Inducible Costimulator Expressing T Cells Promote Parasitic Growth During Blood Stage Plasmodium berghei ANKA Infection

The lethality of blood stage Plasmodium berghei ANKA (PbA) infection is associated with the expression of T-bet and production of cytokine IFN-γ. Expression of inducible costimulator (ICOS) and its downstream signaling has been shown to play a critical role in the T-bet expression and IFN-γ producti...

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Bibliographic Details
Main Authors: Gajendra M. Jogdand, Soumya Sengupta, Gargee Bhattacharya, Santosh Kumar Singh, Prakash Kumar Barik, Satish Devadas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
malaria
inducible costimulator
T cells
IFN-γ
T-bet
CD4
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01041/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01041/full

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