Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH

Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH

G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formation, respectively. Herein, we present the crystal str...

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Bibliographic Details
Main Authors: Tim Schulte, Marc D. Panas, Xiao Han, Lucy Williams, Nancy Kedersha, Jonas Simon Fleck, Timothy J. C. Tan, Xaquin Castro Dopico, Anders Olsson, Ainhoa Moliner Morro, Leo Hanke, Johan Nilvebrant, Kim Anh Giang, Per-Åke Nygren, Paul Anderson, Adnane Achour, Gerald M. McInerney
Format: Article
Language:English
Published: The Royal Society 2023-05-01
Series:Open Biology
Subjects:
stress granule
G3BP
caprin-1
crystal structure
condensate
pH
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.220369

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.220369

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