Atractylodin Suppresses TGF-β-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

Atractylodin Suppresses TGF-β-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

Idiopathic pulmonary fibrosis (IPF) is characterized by fibrotic change in alveolar epithelial cells and leads to the irreversible deterioration of pulmonary function. Transforming growth factor-beta 1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) in type 2 lung epithelial cells contribut...

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Bibliographic Details
Main Authors: Kai-Wei Chang, Xiang Zhang, Shih-Chao Lin, Yu-Chao Lin, Chia-Hsiang Li, Ivan Akhrymuk, Sheng-Hao Lin, Chi-Chien Lin
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
idiopathic pulmonary fibrosis
transforming growth factor-beta 1
epithelial-mesenchymal transition
atractylodin
Smad2/3
MAPK
Online Access:https://www.mdpi.com/1422-0067/22/20/11152

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https://www.mdpi.com/1422-0067/22/20/11152

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