The single D380 amino acid substitution increases pneumolysin cytotoxicity toward neuronal cells

The single D380 amino acid substitution increases pneumolysin cytotoxicity toward neuronal cells

Summary: Bacterial meningitis, frequently caused by Streptococcus pneumoniae (pneumococcus), represents a substantial global health threat leading to long-term neurological disorders. This study focused on the cholesterol-binding toxin pneumolysin (PLY) released by pneumococci, specifically examinin...

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Bibliographic Details
Main Authors: Simona Serra, Vittorio Iannotti, Margherita Ferrante, Miguel Tofiño-Vian, Joseph Baxendale, Gilad Silberberg, Thomas P. Kohler, Sven Hammerschmidt, Andrew T. Ulijasz, Federico Iovino
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Biochemistry
Neuroscience
Molecular neuroscience
Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224008058

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224008058

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