PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism

PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism

Summary: Insulin stimulates the conversion of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) to phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), which mediates downstream cellular responses. PI(4,5)P2 is produced by phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks) and by phosphatidylino...

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Bibliographic Details
Main Authors: Diana G. Wang, Marcia N. Paddock, Mark R. Lundquist, Janet Y. Sun, Oksana Mashadova, Solomon Amadiume, Timothy W. Bumpus, Cindy Hodakoski, Benjamin D. Hopkins, Matthew Fine, Amanda Hill, T. Jonathan Yang, Jeremy M. Baskin, Lukas E. Dow, Lewis C. Cantley
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719305431

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http://www.sciencedirect.com/science/article/pii/S2211124719305431

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