A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways

A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways

Abstract Background As a member of the Janus kinase (JAK) family, which includes JAK1, JAK2 and JAK3, tyrosine kinase 2 (TYK2) plays an important role in signal transduction and immune system regulation. Moreover, it is also involved in the development of many types of inflammatory and autoimmune di...

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Bibliographic Details
Main Authors: Celia X.-J. Chen, Wei Zhang, Shulan Qu, Fucan Xia, Yidong Zhu, Bo Chen
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cell Communication and Signaling
Subjects:
TYK2
JAK
Cytokine pathway
Pseudokinase regulatory domain
Allosteric inhibitor
Psoriasis
Online Access:https://doi.org/10.1186/s12964-023-01299-7

Internet

https://doi.org/10.1186/s12964-023-01299-7

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