Deletion of Cryab increases the vulnerability of mice to the addiction-like effects of the cannabinoid JWH-018 via upregulation of striatal NF-κB expression

Deletion of Cryab increases the vulnerability of mice to the addiction-like effects of the cannabinoid JWH-018 via upregulation of striatal NF-κB expression

Synthetic cannabinoids have exhibited unpredictable abuse liabilities, especially self-administration (SA) responses in normal rodent models, despite seemingly inducing addiction-like effects in humans. Thus, an efficient pre-clinical model must be developed to determine cannabinoid abuse potential...

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Bibliographic Details
Main Authors: Leandro Val Sayson, Darlene Mae Ortiz, Hyun Jun Lee, Mikyung Kim, Raly James Perez Custodio, Jaesuk Yun, Chae Hyeon Lee, Yong Sup Lee, Hye Jin Cha, Jae Hoon Cheong, Hee Jin Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
cannabinoid
Cryab
JWH-018
neuroinflammation
NF-κB
synaptic plasticity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1135929/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1135929/full

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