Receptor oligomerization in family B1 of G-protein-coupled receptors: Focus on BRET investigations and the link between GPCR oligomerization and binding cooperativity

Receptor oligomerization in family B1 of G-protein-coupled receptors: Focus on BRET investigations and the link between GPCR oligomerization and binding cooperativity

The superfamily of the seven transmembrane G-protein-coupled receptors (7TM/GPCRs) is the largest family of membrane-associated receptors. GPCRs are involved in the pathophysiology of numerous human diseases, and they constitute an estimated 30-40 % of all drug targets.During the last two decades, G...

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Bibliographic Details
Main Authors: Sarah Norklit Roed, Anne eOrgaard, Rasmus eJorgensen, Pierre eDe Meyts
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Endocrinology
Subjects:
GPCRs
Family B1
Oligomerization
BRET
Binding cooperativity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00062/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00062/full

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