Synthesis of Novel <i>ent</i>-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells

Synthesis of Novel <i>ent</i>-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells

We have designed and synthesized 6 <i>ent</i>-Kaurane-type diterpenoid derivatives containing &#945;,&#946;-unsaturated ketone moieties. In vitro, activity was evaluated against three human tumor cell lines and a rat myogenic cell line (HepG2, NSCLC-H292, SNU-1040, L6) by MTT ass...

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Bibliographic Details
Main Authors: Yu Hu, Xiao-Nian Li, Ze-Jin Ma, Pema-Tenzin Puno, Yong Zhao, Yan Zhao, Ye-Zhi Xiao, Wei Zhang, Jing-Ping Liu
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
<i>ent</i>-kaurane-type diterpenoid derivatives
antitumor
synthesis
Online Access:https://www.mdpi.com/1420-3049/23/12/3216

Internet

https://www.mdpi.com/1420-3049/23/12/3216

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