A need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1

A need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1

hERG, the pore-forming subunit of the rapid component of the delayed rectifier K+ current, plays a key role in ventricular repolarization. Mutations in the KCNH2 gene encoding hERG are associated with several cardiac rhythmic disorders, mainly the Long QT syndrome (LQTS) characterized by prolonged v...

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Bibliographic Details
Main Authors: Malak Alameh, Barbara Ribeiro Oliveira-Mendes, Florence Kyndt, Jordan Rivron, Isabelle Denjoy, Florian Lesage, Jean-Jacques Schott, Michel De Waard, Gildas Loussouarn
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Physiology
Subjects:
KCNH2 gene
variants
electrophysiology
long QT syndrome
phenotyping
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1132533/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1132533/full

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