A need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1

A need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1

hERG, the pore-forming subunit of the rapid component of the delayed rectifier K+ current, plays a key role in ventricular repolarization. Mutations in the KCNH2 gene encoding hERG are associated with several cardiac rhythmic disorders, mainly the Long QT syndrome (LQTS) characterized by prolonged v...

Full description

Bibliographic Details
Main Authors: Malak Alameh, Barbara Ribeiro Oliveira-Mendes, Florence Kyndt, Jordan Rivron, Isabelle Denjoy, Florian Lesage, Jean-Jacques Schott, Michel De Waard, Gildas Loussouarn
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Physiology
Subjects:
KCNH2 gene
variants
electrophysiology
long QT syndrome
phenotyping
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1132533/full

Similar Items

Similar Items