Apoptosis as Driver of Therapy-Induced Cancer Repopulation and Acquired Cell-Resistance (CRAC): A Simple In Vitro Model of Phoenix Rising in Prostate Cancer

Apoptosis as Driver of Therapy-Induced Cancer Repopulation and Acquired Cell-Resistance (CRAC): A Simple In Vitro Model of Phoenix Rising in Prostate Cancer

Apoptotic cells stimulate compensatory proliferation through the caspase-3-cPLA-2-COX-2-PGE-2-STAT3 Phoenix Rising pathway as a healing process in normal tissues. Phoenix Rising is however usurped in cancer, potentially nullifying pro-apoptotic therapies. Cytotoxic therapies also promote cancer cell...

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Bibliographic Details
Main Authors: Francesca Corsi, Francesco Capradossi, Andrea Pelliccia, Stefania Briganti, Emanuele Bruni, Enrico Traversa, Francesco Torino, Albrecht Reichle, Lina Ghibelli
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
caspase-3
chemoresistance
XIAP
PC3
LNCaP
PGE-2
Online Access:https://www.mdpi.com/1422-0067/23/3/1152

Internet

https://www.mdpi.com/1422-0067/23/3/1152

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