Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites

Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites

Neurodegenerative diseases (NDs) are generally considered proteinopathies but whereas this may initiate disease in familial cases, onset in sporadic diseases may originate from a gradually disrupted organellar homeostasis. Herein, endolysosomal abnormalities, mitochondrial dysfunction, endoplasmic r...

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Bibliographic Details
Main Authors: Stephanie Vrijsen, Céline Vrancx, Mara Del Vecchio, Johannes V. Swinnen, Patrizia Agostinis, Joris Winderickx, Peter Vangheluwe, Wim Annaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Neuroscience
Subjects:
endolysosome
mitochondria
neurodegenerative disease
inter-organellar communication
lipid metabolism
membrane contact site
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.900338/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.900338/full

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