Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids

Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids

Glucocorticoids (GC) affect neuronal plasticity, development and function of the nervous system by inhibiting neurotrophin-induced Trk signaling. It has been established that pretreatment with dexamethasone (DEX) restricts Neurotrophin-induced neurite outgrowth by inhibiting Trk-dependent activation...

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Bibliographic Details
Main Authors: Facundo Ferrero Restelli, Fernando Federicci, Fernanda Ledda, Gustavo Paratcha
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neurotrophins
Trk receptors
glucocorticoids
Sprouty4
Erk/MAPK pathway
neuronal differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1090824/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1090824/full

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