Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay.

Conventional assays for quantification of allo-reactive T-cell precursor frequencies (PF) are relatively insensitive. We present a robust assay for quantification of PF of T-cells with direct donor-specificity, and establish the kinetics of circulating donor-specific T cells after liver transplantat...

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Bibliographic Details
Main Authors: Ozlem Tapirdamaz, Shanta Mancham, Luc J W van der Laan, Geert Kazemier, Kris Thielemans, Herold J Metselaar, Jaap Kwekkeboom
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3012075?pdf=render