Quantitative Ex Vivo MRI Changes due to Progressive Formalin Fixation in Whole Human Brain Specimens: Longitudinal Characterization of Diffusion, Relaxometry, and Myelin Water Fraction Measurements at 3T

Quantitative Ex Vivo MRI Changes due to Progressive Formalin Fixation in Whole Human Brain Specimens: Longitudinal Characterization of Diffusion, Relaxometry, and Myelin Water Fraction Measurements at 3T

PurposePostmortem MRI can be used to reveal important pathologies and establish radiology–pathology correlations. However, quantitative MRI values are altered by tissue fixation. Therefore, the purpose of this study was to investigate time-dependent effects of formalin fixation on MRI relaxometry (T...

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Bibliographic Details
Main Authors: Anwar S. Shatil, Md Nasir Uddin, Kant M. Matsuda, Chase R. Figley
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Medicine
Subjects:
ex vivo
fixation
formalin
longitudinal
postmortem
human brain
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2018.00031/full

Internet

http://journal.frontiersin.org/article/10.3389/fmed.2018.00031/full

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