Topical Tenofovir Pre-exposure Prophylaxis and Mucosal HIV-Specific Fc-Mediated Antibody Activities in Women

Topical Tenofovir Pre-exposure Prophylaxis and Mucosal HIV-Specific Fc-Mediated Antibody Activities in Women

The RV144 HIV-vaccine trial highlighted the importance of envelope-specific non-neutralizing antibody (nNAb) Fc-mediated functions as immune correlates of reduced risk of infection. Since pre-exposure prophylaxis (PrEP) and HIV-vaccines are being used as a combination prevention strategy in at risk...

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Bibliographic Details
Main Authors: Kimone Leigh Fisher, Jennifer M. Mabuka, Aida Sivro, Sinaye Ngcapu, Jo-Ann Shelley Passmore, Farzana Osman, Bongiwe Ndlovu, Quarraisha Abdool Karim, Salim S. Abdool Karim, Amy W. Chung, Cheryl Baxter, Derseree Archary
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
Fc-mediated activity
tenofovir
HIV
women
ADCC–antibody dependent cellular cytotoxicity
ADNP
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01274/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01274/full

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