Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury

Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury

Abstract The lectin pathway (LP) of complement mediates inflammatory processes linked to tissue damage and loss of function following traumatic brain injury (TBI). LP activation triggers a cascade of proteolytic events initiated by LP specific enzymes called MASPs (for Mannan-binding lectin Associat...

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Bibliographic Details
Main Authors: Domenico Mercurio, Francesca Pischiutta, Serena Seminara, Francesca Tribuzio, Ilaria Lisi, Laura Pasetto, Valentina Bonetto, Maria-Grazia De Simoni, Wilhelm Schwaeble, Sadam Yaseen, Thomas Dudler, Elisa R. Zanier, Stefano Fumagalli
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Neuroinflammation
Subjects:
Complement system
Traumatic brain injury
Pharmacology
Mannan-binding lectin-associated serine proteases
Online Access:https://doi.org/10.1186/s12974-024-03133-4

Internet

https://doi.org/10.1186/s12974-024-03133-4

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