Impact of protein and small molecule interactions on kinase conformations

Impact of protein and small molecule interactions on kinase conformations

Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of such disease-associated kinases using the high sensit...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair, Veronika Sexl, Pascal Meier, Teresa Kaserer, Eduard Stefan
स्वरूप: लेख
भाषा:English
प्रकाशित: eLife Sciences Publications Ltd 2024-08-01
श्रृंखला:eLife
विषय:
kinase conformation
target engagement
drug interactions
kinase scaffolding function
kinase complex formation
cell-based reporter assay
ऑनलाइन पहुंच:https://elifesciences.org/articles/94755

इंटरनेट

https://elifesciences.org/articles/94755

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