Impact of protein and small molecule interactions on kinase conformations

Impact of protein and small molecule interactions on kinase conformations

Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of such disease-associated kinases using the high sensit...

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Autors principals:	Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair, Veronika Sexl, Pascal Meier, Teresa Kaserer, Eduard Stefan
Format:	Article
Idioma:	English
Publicat:	eLife Sciences Publications Ltd 2024-08-01
Col·lecció:	eLife
Matèries:	kinase conformation target engagement drug interactions kinase scaffolding function kinase complex formation cell-based reporter assay
Accés en línia:	https://elifesciences.org/articles/94755

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