Impact of protein and small molecule interactions on kinase conformations

Impact of protein and small molecule interactions on kinase conformations

Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of such disease-associated kinases using the high sensit...

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Podrobná bibliografie
Hlavní autoři: Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair, Veronika Sexl, Pascal Meier, Teresa Kaserer, Eduard Stefan
Médium: Článek
Jazyk:English
Vydáno: eLife Sciences Publications Ltd 2024-08-01
Edice:eLife
Témata:
kinase conformation
target engagement
drug interactions
kinase scaffolding function
kinase complex formation
cell-based reporter assay
On-line přístup:https://elifesciences.org/articles/94755

Internet

https://elifesciences.org/articles/94755

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