Pharmacological Inhibition of Cyclin-Dependent Kinases Triggers Anti-Fibrotic Effects in Hepatic Stellate Cells In Vitro

Pharmacological Inhibition of Cyclin-Dependent Kinases Triggers Anti-Fibrotic Effects in Hepatic Stellate Cells In Vitro

Liver fibrosis is a wound healing process in response to chronic liver injury, which is characterized by the accumulation of extracellular collagen produced by Hepatic Stellate Cells (HSCs). This process involves cell cycle re-entry and proliferation of normally quiescent HSCs controlled by cyclins...

Full description

Bibliographic Details
Main Authors: Anna Hübbers, Julia Hennings, Daniela Lambertz, Ute Haas, Christian Trautwein, Yulia A. Nevzorova, Roland Sonntag, Christian Liedtke
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
hepatic stellate cells
liver fibrosis
cyclin-dependent kinase
CR8
cell cycle
DNA repair
Online Access:https://www.mdpi.com/1422-0067/21/9/3267

Internet

https://www.mdpi.com/1422-0067/21/9/3267

Similar Items