Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome

Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome

Aims: Macrophage (MΦ) infiltration during myocardial infarction (MI) amplifies cardiac inflammation and remodeling. We investigated whether activation of the NRLP3 inflammasome by a calcium sensing receptor (CaSR) in MΦ subsets contributes to cardiac remodeling following MI. Methods and Results: Inf...

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Bibliographic Details
Main Authors: Wenxiu Liu, Xin Zhang, Meng Zhao, Xiaohui Zhang, Jinyu Chi, Yue Liu, Fang Lin, Yu Fu, Dandan Ma, Xinhua Yin
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
NLRP3 inflammasome
Cardiac remodeling
Myocardial infarction
Macrophage
Calcium sensing receptor
Online Access:http://www.karger.com/Article/FullText/374048

Internet

http://www.karger.com/Article/FullText/374048

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