Protein Subdomain Enrichment of NUP155 Variants Identify a Novel Predicted Pathogenic Hotspot

Protein Subdomain Enrichment of NUP155 Variants Identify a Novel Predicted Pathogenic Hotspot

Functional variants in nuclear envelope genes are implicated as underlying causes of cardiopathology. To examine the potential association of single nucleotide variants of nucleoporin genes with cardiac disease, we employed a prognostic scoring approach to investigate variants of NUP155, a nucleopor...

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Bibliographic Details
Main Authors: Riley J. Leonard, Claudia C. Preston, Melanie E. Gucwa, Yohannes Afeworki, Arielle S. Selya, Randolph S. Faustino
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
single nucleotide variants (SNV)
nucleoporins
network biology and protein-protein interactions
atrial fibrillation (AF)
nuclear envelope (NE)
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2020.00008/full

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https://www.frontiersin.org/article/10.3389/fcvm.2020.00008/full

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