Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries.
Somite segmentation depends on a gene expression oscillator or clock in the posterior presomitic mesoderm (PSM) and on read-out machinery in the anterior PSM to convert the pattern of clock phases into a somite pattern. Notch pathway mutations disrupt somitogenesis, and previous studies have suggest...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-02-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2222926?pdf=render |