Local Ancestry Adjusted Allelic Association Analysis Robustly Captures Tuberculosis Susceptibility Loci

Local Ancestry Adjusted Allelic Association Analysis Robustly Captures Tuberculosis Susceptibility Loci

Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis, is a complex disease. The risk of developing active TB is in part determined by host genetic factors. Most genetic studies investigating TB susceptibility fail to replicate association signals particularly across diverse populations....

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Bibliographic Details
Main Authors: Yolandi Swart, Caitlin Uren, Paul D. van Helden, Eileen G. Hoal, Marlo Möller
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Genetics
Subjects:
South Africa
admixture mapping
TB susceptibility
ancestry-specific risk alleles
local ancestry adjustments
population genetics
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.716558/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.716558/full

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