GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma

GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma

Abstract Background The ETS transcription factor GABPA has long been thought of as an oncogenic factor and recently suggested as a target for cancer therapy due to its critical effect on telomerase activation, but the role of GABPA in clear cell renal cell carcinoma (ccRCC) is unclear. In addition,...

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Bibliographic Details
Main Authors: Zhiqing Fang, Ning Zhang, Xiaotian Yuan, Xiangling Xing, Xiaofeng Li, Xin Qin, Zhengfang Liu, Shiyong Neo, Cheng Liu, Feng Kong, Magnus Björkholm, Yidong Fan, Dawei Xu
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ccRCC
GABPA
L-2-HG
Oncometabolite
TGFBR2
Online Access:https://doi.org/10.1186/s13046-022-02382-6

Internet

https://doi.org/10.1186/s13046-022-02382-6

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