Dose-Dependent Effects of a Novel Selective EP<sub>4</sub> Prostaglandin Receptor Agonist on Treatment of Critical Size Femoral Bone Defects in a Rat Model

Dose-Dependent Effects of a Novel Selective EP<sub>4</sub> Prostaglandin Receptor Agonist on Treatment of Critical Size Femoral Bone Defects in a Rat Model

Difficulties in treating pseudarthrosis and critical bone defects are still evident in physicians’ clinical routines. Bone morphogenetic protein 2 (BMP-2) has shown promising osteoinductive results but also considerable side effects, not unexpected given that it is a morphogen. Thus, the bone regene...

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Bibliographic Details
Main Authors: Corina Vater, Elisabeth Mehnert, Henriette Bretschneider, Julia Bolte, Lisa Findeisen, Lucas-Maximilian Matuszewski, Stefan Zwingenberger
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomedicines
Subjects:
critical-sized bone defect
bone regeneration
tissue regeneration
scaffold
EP<sub>4</sub> receptor agonist
BMP-2
Online Access:https://www.mdpi.com/2227-9059/9/11/1712

Internet

https://www.mdpi.com/2227-9059/9/11/1712

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