Antibody-Drug Conjugates Targeting Tumor-Specific Mucin Glycoepitopes

Antibody-Drug Conjugates Targeting Tumor-Specific Mucin Glycoepitopes

Finding the ideal epitope to target is a key element for the development of an antibody-drug conjugate (ADC). To maximize drug delivery to tumor cells and reduce side effects, this epitope should be specific to cancer cells and spare all normal tissue. During cancer progression, glycosylation pathwa...

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Bibliographic Details
Main Authors: Julyanne Brassard, Michael R. Hughes, Calvin D. Roskelley, Kelly M. McNagny
Format: Article
Language:English
Published: IMR Press 2022-11-01
Series:Frontiers in Bioscience-Landmark
Subjects:
glycoepitope
mucin
antibody-drug conjugate
cancer treatment
Online Access:https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711301

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https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711301

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