Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis

Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis

Abstract Background Chronic inflammatory pain significantly reduces the quality of life and lacks effective interventions. In recent years, human umbilical cord mesenchymal stem cells (huc-MSCs)-derived exosomes have been used to relieve neuropathic pain and other inflammatory diseases as a promisin...

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Bibliographic Details
Main Authors: Tong Hua, Mei Yang, Honghao Song, Erliang Kong, Mengqiu Deng, Yongchang Li, Jian Li, Zhixiao Liu, Hailong Fu, Yue Wang, Hongbin Yuan
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Nanobiotechnology
Subjects:
Huc-MSCs-derived exosomes
Inflammatory pain
Microglia
Pyroptosis
Autophagy
Online Access:https://doi.org/10.1186/s12951-022-01522-6

Internet

https://doi.org/10.1186/s12951-022-01522-6

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