Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank

Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank

Summary: Background: Ocular diseases may exhibit common clinical symptoms and epidemiological comorbidity. However, the extent of pleiotropic mechanisms across ocular diseases remains unclear. We aim to examine shared genetic etiology in age-related macular degeneration (AMD), diabetic retinopathy...

Full description

Bibliographic Details
Main Authors: Zhengbo Xue, Jian Yuan, Fukun Chen, Yinghao Yao, Shilai Xing, Xiangyi Yu, Kai Li, Chenxiao Wang, Jinhua Bao, Jia Qu, Jianzhong Su, Hao Chen
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:EBioMedicine
Subjects:
Ocular diseases
Cross-disease genetics
GWAS
Genetic correlation
Pleiotropy
Retinal development
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422003425

Internet

http://www.sciencedirect.com/science/article/pii/S2352396422003425

Similar Items