Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank

Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank

Summary: Background: Ocular diseases may exhibit common clinical symptoms and epidemiological comorbidity. However, the extent of pleiotropic mechanisms across ocular diseases remains unclear. We aim to examine shared genetic etiology in age-related macular degeneration (AMD), diabetic retinopathy...

Full description

Bibliographic Details
Main Authors:	Zhengbo Xue, Jian Yuan, Fukun Chen, Yinghao Yao, Shilai Xing, Xiangyi Yu, Kai Li, Chenxiao Wang, Jinhua Bao, Jia Qu, Jianzhong Su, Hao Chen
Format:	Article
Language:	English
Published:	Elsevier 2022-08-01
Series:	EBioMedicine
Subjects:	Ocular diseases Cross-disease genetics GWAS Genetic correlation Pleiotropy Retinal development
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396422003425

Similar Items

Investigating the shared genetic architecture between COVID-19 and obesity: a large-scale genome wide cross-trait analysis
by: Yanjing Chen, et al.
Published: (2024-01-01)

Pleiotropic Effects of mTOR and Autophagy During Development and Aging
by: Kathrin Schmeisser, et al.
Published: (2019-09-01)

Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices
by: BaHammam AS, et al.
Published: (2024-11-01)

Phenome-wide association study on miRNA-related sequence variants: the UK Biobank
by: Rima Mustafa, et al.
Published: (2023-11-01)

Shared genetic architecture between the two neurodegenerative diseases: Alzheimer’s disease and glaucoma
by: Chunwen Zheng, et al.
Published: (2022-09-01)

A survey of genome-wide association studies, polygenic scores and UK Biobank highlights resources for autoimmune disease genetics
by: Rochi Saurabh, et al.
Published: (2022-08-01)

Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation
by: CM Schooling, et al.
Published: (2020-08-01)

Detection of Genomic Regions with Pleiotropic Effects for Growth and Carcass Quality Traits in the Rubia Gallega Cattle Breed
by: Maria Martinez-Castillero, et al.
Published: (2021-06-01)

Corrigendum: Genetic overlap and causality between COVID-19 and multi-site chronic pain: the importance of immunity
by: Yanjing Chen, et al.
Published: (2024-04-01)

Genetic overlap and causality between COVID-19 and multi-site chronic pain: the importance of immunity
by: Yanjing Chen, et al.
Published: (2024-03-01)

Genomic regions, candidate genes, and pleiotropic variants associated with physiological and anatomical indicators of heat stress response in lactating sows
by: Letícia Fernanda de Oliveira, et al.
Published: (2024-05-01)

Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
by: Christopher W Bakerlee, et al.
Published: (2021-10-01)

Investigating Shared Genetic Bases between Psychiatric Disorders, Cardiometabolic and Sleep Traits Using K-Means Clustering and Local Genetic Correlation Analysis
by: Gianpaolo Zammarchi, et al.
Published: (2022-11-01)

Pleiotropic expression quantitative trait loci are enriched in enhancers and transcription factor binding sites and impact more genes
by: Aitor González, et al.
Published: (2024-12-01)

More evidence for widespread antagonistic pleiotropy in polymorphic disease alleles
by: Cynthia Lockwood, et al.
Published: (2024-06-01)

Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system
by: Vera Fominykh, et al.
Published: (2023-07-01)

Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
by: Ole Kristian Drange, et al.
Published: (2019-03-01)

Rare copy-number variants as modulators of common disease susceptibility
by: Chiara Auwerx, et al.
Published: (2024-01-01)

Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data
by: Olivia J. Veatch, et al.
Published: (2022-06-01)

Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations
by: Mohammad Yaser Anwar, et al.
Published: (2022-09-01)

A novel framework with automated horizontal pleiotropy adjustment in mendelian randomization
by: Zhaotong Lin
Published: (2024-10-01)

Inheritance of Indehiscent Capsule Character, Heritability and Genetic Advance Analyses in the Segregation Generations of Dehiscent x Indehiscent Capsules in Sesame
by: Engin Yol, et al.
Published: (2019-03-01)

Evolution of haploid and diploid populations reveals common, strong, and variable pleiotropic effects in non-home environments
by: Vivian Chen, et al.
Published: (2023-10-01)

Integrative analysis for big data in genomics
by: Xianghong HU, et al.
Published: (2019-07-01)

TSABL: Trait Specific Annotation Based Locus predictor
by: Kim Lorenz, et al.
Published: (2022-06-01)

Shared Genetic Links Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease
by: Hua Di, et al.
Published: (2024-11-01)

Establishing plausibility of cardiovascular adverse effects of immunotherapies using Mendelian randomisation
by: Nhu Ngoc Le, et al.
Published: (2023-05-01)

DisVar: an R library for identifying variants associated with diseases using large-scale personal genetic information
by: Khunanon Chanasongkhram, et al.
Published: (2023-09-01)

Leveraging primate-specific genomic information for genetic studies of complex diseases
by: Wen-Hua Wei, et al.
Published: (2023-03-01)

Reduced signal for polygenic adaptation of height in UK Biobank
by: Jeremy J Berg, et al.
Published: (2019-03-01)

The landscape of rare genetic variation associated with inflammatory bowel disease and Parkinson’s disease comorbidity
by: Meltem Ece Kars, et al.
Published: (2024-05-01)

Pleiotropic effects of melanin pigmentation: haemoparasite infection intensity but not telomere length is associated with plumage morph in black sparrowhawks
by: Edmund Rodseth, et al.
Published: (2024-04-01)

Editorial: The Genetic and Environmental Basis for Diseases in Understudied Populations
by: Nicola Mulder, et al.
Published: (2020-09-01)

The Role of <i>TP53</i> in Adaptation and Evolution
by: Konstantinos Voskarides, et al.
Published: (2023-02-01)

Phenome Wide Association Studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index
by: Robert Michael Cronin, et al.
Published: (2014-08-01)

Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases
by: Fasil Tekola-Ayele, et al.
Published: (2019-04-01)

Modulation of Reactive Oxygen Species Homeostasis as a Pleiotropic Effect of Commonly Used Drugs
by: Carolin Thomas, et al.
Published: (2022-06-01)

Natural variation in Drosophila shows weak pleiotropic effects
by: Eirini Christodoulaki, et al.
Published: (2022-05-01)

Genetic associations with disease in populations with Indigenous American ancestries
by: Lucas Vicuña
Published: (2024-09-01)

Mutation network-based understanding of pleiotropic and epistatic mutational behavior of Enterococcus faecalis FMN-dependent azoreductase
by: Jinyan Sun, et al.
Published: (2017-12-01)