A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

Summary: Early-onset Parkinson's disease-associated PINK1-Parkin signaling maintains mitochondrial health. Therapeutic approaches for enhancing PINK1-Parkin signaling present a potential strategy for treating various diseases caused by mitochondrial dysfunction. We report two chemical enhancers...

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Bibliographic Details
Main Authors: Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Osamu Sano, Hidehisa Iwata, Kei-ichi Ishikawa, Hideyuki Okano, Wado Akamatsu, Yuzuru Imai, Nobutaka Hattori
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
Biological Sciences
Neuroscience
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220302339

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220302339

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