TSG-6 Inhibits Oxidative Stress and Induces M2 Polarization of Hepatic Macrophages in Mice With Alcoholic Hepatitis via Suppression of STAT3 Activation

TSG-6 Inhibits Oxidative Stress and Induces M2 Polarization of Hepatic Macrophages in Mice With Alcoholic Hepatitis via Suppression of STAT3 Activation

Tumor necrosis factor (TNF)-α-stimulated protein 6 (TSG-6) is a secreted protein with diverse tissue protective and anti-inflammatory properties. We aimed to investigate its effects in treating mice with alcoholic hepatitis (AH) and the associated mechanisms. AH was induced in 8–10 week female C57BL...

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Bibliographic Details
Main Authors: Yue-Meng Wan, Hua-Mei Wu, Yu-Hua Li, Zhi-Yuan Xu, Jin-Hui Yang, Chang Liu, Yue-Feng He, Men-Jie Wang, Xi-Nan Wu, Yuan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
TSG-6
alcoholic hepatitis
oxidative stress
macrophage polarization
STAT3 activation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00010/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00010/full

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