IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent manner

IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent manner

Abstract Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer (CRC) oncogenesis, progression, and drug resistance remain unclear. This study fou...

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Main Authors: Li-Jie Chen, Hui-Ye Liu, Zhi-Yuan Xiao, Ting Qiu, Dan Zhang, Ling-Jie Zhang, Fang-Yi Han, Guo-Jun Chen, Xue-Mei Xu, Jiong-Hua Zhu, Yan-Qing Ding, Shu-Yang Wang, Ya-Ping Ye, Hong-Li Jiao
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06099-y

Internet

https://doi.org/10.1038/s41419-023-06099-y

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