Development and Validation of Liquid Chromatography-Based Methods to Assess the Lipophilicity of Cytotoxic Platinum(IV) Complexes

Development and Validation of Liquid Chromatography-Based Methods to Assess the Lipophilicity of Cytotoxic Platinum(IV) Complexes

Lipophilicity is a crucial parameter for drug discovery, usually determined by the logarithmic partition coefficient (Log P) between octanol and water. However, the available detection methods have restricted the widespread use of the partition coefficient in inorganic medicinal chemistry, and recen...

Full description

Bibliographic Details
Main Authors: Matthias H. M. Klose, Sarah Theiner, Hristo P. Varbanov, Doris Hoefer, Verena Pichler, Markus Galanski, Samuel M. Meier-Menches, Bernhard K. Keppler
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Inorganics
Subjects:
φ<sub>0</sub>
anticancer agents
chromatographic lipophilicity parameter
distribution coefficient
HPLC
lipophilicity
Log k<sub>w</sub>
Log P
partition coefficient
platinum(IV)
Online Access:https://www.mdpi.com/2304-6740/6/4/130

Internet

https://www.mdpi.com/2304-6740/6/4/130

Similar Items