Suppressing NK Cells by Astragaloside IV Protects Against Acute Ischemic Stroke in Mice Via Inhibiting STAT3

Suppressing NK Cells by Astragaloside IV Protects Against Acute Ischemic Stroke in Mice Via Inhibiting STAT3

Natural killer (NK) cells, a key member of innate lymphocytes, are a promising immunotherapeutic target for ischemic stroke. Astragaloside IV (ASIV) is isolated from Astragalus mongholicus Bunge (Fabaceae), a herbal medicine possessing immunomodulatory ability. This study investigated the effect of...

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Bibliographic Details
Main Authors: Shichun Li, Baokai Dou, Shi Shu, Luyao Wei, Shiguo Zhu, Zunji Ke, Zhifei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
natural killer cells
brain ischemia
astragaloside IV
oxygen-glucose deprivation
signal transducer and activator of transcription 3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.802047/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.802047/full

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