Automated protein subfamily identification and classification.

Function prediction by homology is widely used to provide preliminary functional annotations for genes for which experimental evidence of function is unavailable or limited. This approach has been shown to be prone to systematic error, including percolation of annotation errors through sequence data...

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Bibliographic Details
Main Authors: Duncan P Brown, Nandini Krishnamurthy, Kimmen Sjölander
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-08-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.0030160