Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner

Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner

Context Gambogic amide (GA-amide) is a non-peptide molecule that has high affinity for tropomyosin receptor kinase A (TrkA) and possesses robust neurotrophic activity, but its effect on angiogenesis is unclear. Objective The study investigates the antiangiogenic effect of GA-amide on endothelial cel...

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Bibliographic Details
Main Authors: Tongtong Sui, Bojun Qiu, Jiaorong Qu, Yuxin Wang, Kunnian Ran, Wei Han, Xiaozhong Peng
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Pharmaceutical Biology
Subjects:
antiangiogenic
akt/mtor
plcγ/erk1/2
anticancer
phytochemicals
Online Access:http://dx.doi.org/10.1080/13880209.2021.1998140

Internet

http://dx.doi.org/10.1080/13880209.2021.1998140

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