Crebanine, an aporphine alkaloid, induces cancer cell apoptosis through PI3K-Akt pathway in glioblastoma multiforme

Crebanine, an aporphine alkaloid, induces cancer cell apoptosis through PI3K-Akt pathway in glioblastoma multiforme

Glioblastoma multiforme (GBM) is one of the most prevalent and lethal primary central nervous system malignancies. GBM is notorious for its high rates of recurrence and therapy resistance and the PI3K/Akt pathway plays a pivotal role in its malignant behavior. Crebanine (CB), an alkaloid capable of...

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Bibliographic Details
Main Authors: Poh-Shiow Yeh, Chien-Te Liu, Chia-Ying Yu, Ya-Chuan Chang, Shu-Yu Lin, Yun-Chen Li, Yu-Ze Luan, Wen-Wei Sung
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Pharmacology
Subjects:
crebanine
glioblastoma multiforme
brain tumor
natural product
aporphine alkaloid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1419044/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1419044/full

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