Oxidative Stress Promotes Liver Cancer Metastasis via RNF25‐Mediated E‐Cadherin Protein Degradation

Oxidative Stress Promotes Liver Cancer Metastasis via RNF25‐Mediated E‐Cadherin Protein Degradation

Abstract Loss of E‐cadherin (ECAD) is required in tumor metastasis. Protein degradation of ECAD in response to oxidative stress is found in metastasis of hepatocellular carcinoma (HCC) and is independent of transcriptional repression as usually known. Mechanistically, protein kinase A (PKA) senses o...

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Bibliographic Details
Main Authors: Zhao Huang, Li Zhou, Jiufei Duan, Siyuan Qin, Jingwen Jiang, Haining Chen, Kui Wang, Rui Liu, Minlan Yuan, Xiangdong Tang, Edouard C. Nice, Yuquan Wei, Wei Zhang, Canhua Huang
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
cancer metastasis
oxidative stress
post‐translational modifications
redox signaling
Online Access:https://doi.org/10.1002/advs.202306929

Internet

https://doi.org/10.1002/advs.202306929

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