Study of Formulation and Process Variables for Optimization of Piroxicam Nanosuspension Using 3<sup>2</sup> Factorial Design to Improve Solubility and In Vitro Bioavailability

Study of Formulation and Process Variables for Optimization of Piroxicam Nanosuspension Using 3<sup>2</sup> Factorial Design to Improve Solubility and In Vitro Bioavailability

Piroxicam is a Biopharmaceutical Classification System (BCS) Class II drug having poor aqueous solubility and a short half-life. The rationale behind the present research was to develop a Piroxicam nanosuspension to enhance the solubility and thereby the in vitro bioavailability of the drug. Piroxic...

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Bibliographic Details
Main Authors: Yahya Alhamhoom, Sandip M. Honmane, Umme Hani, Riyaz Ali M. Osmani, Geetha Kandasamy, Rajalakshimi Vasudevan, Sharanya Paramshetti, Ravindra R. Dudhal, Namrata K. Kengar, Manoj S. Charde
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Polymers
Subjects:
polymers
nanosuspension
solubility
bioavailability
anti-solvent precipitation
in vitro drug dissolution
Online Access:https://www.mdpi.com/2073-4360/15/3/483

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https://www.mdpi.com/2073-4360/15/3/483

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