Homologous Recombination Repair Mechanisms in Serous Endometrial Cancer

Homologous Recombination Repair Mechanisms in Serous Endometrial Cancer

Serous endometrial cancer (SEC) resembles high-grade serous ovarian cancer (HGSOC) genetically and clinically, with recurrent copy number alterations, <i>TP53</i> mutations and a poor prognosis. Thus, SEC patients may benefit from targeted treatments used in HGSOC, e.g., PARP inhibitors....

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Bibliographic Details
Main Authors: Jenny-Maria Jönsson, Maria Bååth, Ida Björnheden, Irem Durmaz Sahin, Anna Måsbäck, Ingrid Hedenfalk
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
serous endometrial cancer
homologous recombination repair deficiency
DNA repair
copy-number variation
PARP inhibition
Online Access:https://www.mdpi.com/2072-6694/13/2/254

Internet

https://www.mdpi.com/2072-6694/13/2/254

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