Fatty Acid-Activated Proton Transport by Bisaryl Anion Transporters Depolarises Mitochondria and Reduces the Viability of MDA-MB-231 Breast Cancer Cells

Fatty Acid-Activated Proton Transport by Bisaryl Anion Transporters Depolarises Mitochondria and Reduces the Viability of MDA-MB-231 Breast Cancer Cells

In respiring mitochondria, the proton gradient across the inner mitochondrial membrane is used to drive ATP production. Mitochondrial uncouplers, which are typically weak acid protonophores, can disrupt this process to induce mitochondrial dysfunction and apoptosis in cancer cells. We have shown tha...

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Bibliographic Details
Main Authors: Edward York, Daniel A. McNaughton, Meryem-Nur Duman, Philip A. Gale, Tristan Rawling
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomolecules
Subjects:
mitochondria
uncouplers
anion transporter
proton transport
membrane
anticancer
Online Access:https://www.mdpi.com/2218-273X/13/8/1202

Internet

https://www.mdpi.com/2218-273X/13/8/1202

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